Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1388)
DME Name Unclear metabolic mechanism (DME-unclear), Bifidobacterium breve
Gene Name DME-unclear
Lineage    Species: Bifidobacterium breve     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium breve
Subspecies: Bifidobacterium breve DSM 20213
Subspecies: Bifidobacterium breve K-110
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        19 Drugs
Primaquine
 Drug Info Approved Malaria ICD11: 1F40 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Terbinafine hydrochloride
 Drug Info Approved Pityriasis versicolor ICD11: 1F2D [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Nizatidine
 Drug Info Approved Peptic ulcer ICD11: DA61 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ranitidine
 Drug Info Approved Peptic ulcer ICD11: DA61 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Paliperidone
 Drug Info Approved Bipolar disorder ICD11: 6A60 [1]
Quinapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Risperidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          5 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Benzbromarone
 Drug Info Phase 4 Hyperuricaemia ICD11: 5C55 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
CBL-954
 Drug Info Discontinued Hepatocellular carcinoma ICD11: 2C12 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
HY-N0791
 Drug Info Preclinical Fatty liver disease ICD11: DB92 [3]
ML-236B
 Drug Info Preclinical Hypertriglyceridaemia ICD11: 5C80 [1]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
3 Metabolism of 6"-O-xylosyltectoridin and tectoridin by human intestinal bacteria and their hypoglycemic and in vitro cytotoxic activities. Biol Pharm Bull. 1999 Dec;22(12):1314-8.

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