Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1391) | |||||
|---|---|---|---|---|---|
| DME Name | Unclear metabolic mechanism (DME-unclear), Bifidobacterium ruminatum | ||||
| Gene Name | DME-unclear | ||||
| Lineage | Species: Bifidobacterium ruminatum (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 32 Drugs | ||||
Bupropion |
Drug Info | Approved | Nicotine dependence | ICD11: 6C4A | [1] |
Methylphenidate |
Drug Info | Approved | Attention deficit hyperactivity disorder | ICD11: 6A05 | [1] |
Irbesartan |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [1] |
Mycophenolate mofetil |
Drug Info | Approved | Crohn disease | ICD11: DD70 | [1] |
Febuxostat |
Drug Info | Approved | Hyperuricaemia | ICD11: 5C55 | [1] |
Deflazacort |
Drug Info | Approved | Muscular dystrophy | ICD11: 8C70 | [1] |
Fluvoxamine maleate |
Drug Info | Approved | Obsessive-compulsive disorder | ICD11: 6B20 | [1] |
Diphenylpyraline |
Drug Info | Approved | Allergy | ICD11: 4A80 | [1] |
Dasatinib |
Drug Info | Approved | Chronic myelogenous leukaemia | ICD11: 2A20 | [1] |
Fluoxetine hydrochloride |
Drug Info | Approved | Depression | ICD11: 6A71 | [1] |
Metoprolol tartrate |
Drug Info | Approved | Angina pectoris | ICD11: BA40 | [1] |
Oxaprozin |
Drug Info | Approved | Rheumatoid arthritis | ICD11: FA20 | [1] |
Riluzole |
Drug Info | Approved | Amyotrophic lateral sclerosis | ICD11: 8B60 | [1] |
Danazol |
Drug Info | Approved | Endometriosis | ICD11: GA10 | [1] |
Omeprazole |
Drug Info | Approved | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
Sulfasalazine |
Drug Info | Approved | Rheumatoid arthritis | ICD11: FA20 | [1] |
Tolazamide |
Drug Info | Approved | Diabetes mellitus | ICD11: 5A10 | [1] |
Losartan potassium |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [1] |
Memantine |
Drug Info | Approved | Alzheimer disease | ICD11: 8A20 | [1] |
Pantoprazole sodium |
Drug Info | Approved | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
Bromocriptine mesylate |
Drug Info | Approved | Parkinsonism | ICD11: 8A00 | [1] |
Entacapone |
Drug Info | Approved | Parkinsonism | ICD11: 8A00 | [1] |
Mebendazole |
Drug Info | Approved | Ascariasis | ICD11: 1F62 | [1] |
Megestrol acetate |
Drug Info | Approved | Breast cancer | ICD11: 2C60 | [1] |
Melphalan |
Drug Info | Approved | Multiple myeloma | ICD11: 2A83 | [1] |
Quinapril |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [1] |
Tinidazole |
Drug Info | Approved | Protozoan infection | ICD11: 1F5Z | [1] |
Amantadine |
Drug Info | Approved | Influenza virus infection | ICD11: 1E30 | [1] |
Norgestimate |
Drug Info | Approved | Acne vulgaris | ICD11: ED80 | [1] |
Oxybutynin chloride |
Drug Info | Approved | Overactive bladder | ICD11: GC50 | [1] |
Ramelteon |
Drug Info | Approved | Insomnia | ICD11: 7A00 | [1] |
Trihexyphenidyl |
Drug Info | Approved | Parkinsonism | ICD11: 8A00 | [1] |
| Drugs in Phase 4 Clinical Trial | Click to Show/Hide the Full List of Drugs: 8 Drugs | ||||
Artemisinin |
Drug Info | Phase 4 | Malaria | ICD11: 1F40 | [1] |
Phenazopyridine |
Drug Info | Phase 4 | Infectious cystitis | ICD11: GC00 | [1] |
Alprenolol |
Drug Info | Phase 4 | Essential hypertension | ICD11: BA00 | [1] |
Trimebutine |
Drug Info | Phase 4 | Irritable bowel syndrome | ICD11: DD91 | [1] |
Milnacipran |
Drug Info | Phase 4 | Asperger syndrome | ICD11: 6A02 | [1] |
Bisacodyl |
Drug Info | Phase 4 | Irritable bowel syndrome | ICD11: DD91 | [1] |
Nafronyl oxalate |
Drug Info | Phase 4 | Arteriosclerosis obliterans | ICD11: BD40 | [1] |
Mebhydrolin |
Drug Info | Phase 4 | Allergy | ICD11: 4A80 | [1] |
| Drugs in Phase 3 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
OPC-12759 |
Drug Info | Phase 3 | Peptic ulcer | ICD11: DA61 | [1] |
| Drugs in Phase 2 Clinical Trial | Click to Show/Hide the Full List of Drugs: 3 Drugs | ||||
Roxatidine |
Drug Info | Phase 2 | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
TU-199 |
Drug Info | Phase 2 | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
BRN-0889798 |
Drug Info | Phase 2 | Keratoconjunctivitis sicca | ICD11: 9A79 | [1] |
| Drugs in Phase 1 Clinical Trial | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
BRN-0498823 |
Drug Info | Phase 1 | Essential hypertension | ICD11: BA00 | [1] |
MN-1695 |
Drug Info | Phase 1 | Gastric ulcer | ICD11: DA60 | [1] |
| Discontinued/withdrawn Drugs | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
WIN-4692 |
Drug Info | Discontinued | Cerebral vasospasm | ICD11: BA85 | [1] |
| Preclinical/investigative Agents | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Diacetamate |
Drug Info | Investigative | Discovery agent | ICD: N.A. | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | ||||
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