Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1392)
DME Name Unclear metabolic mechanism (DME-unclear), Bifidobacterium angulatum
Gene Name DME-unclear
Lineage    Species: Bifidobacterium angulatum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium angulatum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Oxtriphylline
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Q-100154
 Drug Info Phase 2 Hepatocellular carcinoma ICD11: 2C12 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          8 Drugs
HY-N0040
 Drug Info Preclinical Rotavirus gastroenteritis ICD11: 1A22 [3]
Kalopanaxsaponin H
 Drug Info Investigative Diabetes mellitus ICD11: 5A10 [4]
Kalopanaxsaponin I
 Drug Info Investigative Prostate cancer ICD11: 2C82 [4]
Kalopanaxsaponin K
 Drug Info Investigative Rheumatoid arthritis ICD11: FA20 [4]
Ginsenoside Rc
 Drug Info Investigative Diabetes mellitus ICD11: 5A10 [3]
Ginsenoside Rh2
 Drug Info Investigative Breast cancer ICD11: 2C60 [2]
Polyphenols
 Drug Info Investigative Discovery agent ICD: N.A. [5]
Phosphatidylcholine
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio. 2016 Apr 5;7(2):e02210-15.
2 Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63.
3 Interactions between various microbes and ginseng botanicals. Crit Rev Microbiol. 2011 May;37(2):113-20.
4 Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites. Biol Pharm Bull. 2002 Jan;25(1):68-71.
5 Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut. J Agric Food Chem. 2011 Dec 28;59(24):12815-20.

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