Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1406) | |||||
|---|---|---|---|---|---|
| DME Name | Unclear metabolic mechanism (DME-unclear), Collinsella aerofaciens | ||||
| Gene Name | DME-unclear | ||||
| Lineage | Species: Collinsella aerofaciens (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 6 Drugs | ||||
Nefazodone |
Drug Info | Approved | Depression | ICD11: 6A71 | [1] |
Loxapine succinate |
Drug Info | Approved | Schizophrenia | ICD11: 6A20 | [1] |
Fenofibrate |
Drug Info | Approved | Hypertriglyceridaemia | ICD11: 5C80 | [1] |
Pitavastatin calcium |
Drug Info | Approved | Hypertriglyceridaemia | ICD11: 5C80 | [1] |
Zidovudine |
Drug Info | Approved | Human immunodeficiency virus infection | ICD11: 1C60 | [1] |
Capecitabine |
Drug Info | Approved | Colon cancer | ICD11: 2B90 | [1] |
| Drugs in Phase 4 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Trimebutine |
Drug Info | Phase 4 | Irritable bowel syndrome | ICD11: DD91 | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | ||||
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