Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1426)
DME Name	Unclear metabolic mechanism (DME-unclear), Eubacterium cellulosolvens
Gene Name	DME-unclear
Lineage	Species: Eubacterium cellulosolvens (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Eubacteriaceae Genus: Eubacterium Species: Eubacterium cellulosolvens Subspecies: Eubacterium cellulosolvens strain GLH
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human gut.

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs: 1 Drugs
Oxytetracycline	Drug Info	Approved	Urethritis/urethral syndrome	ICD11: GC02	[1]
Drugs in Phase 3 Clinical Trial			Click to Show/Hide the Full List of Drugs: 1 Drugs
BRN-0077922	Drug Info	Phase 3	Influenza virus infection	ICD11: 1E30	[2]
Drugs in Phase 2 Clinical Trial			Click to Show/Hide the Full List of Drugs: 1 Drugs
Q-100154	Drug Info	Phase 2	Hepatocellular carcinoma	ICD11: 2C12	[3]
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 1 Drugs
Ginsenoside Rh2	Drug Info	Investigative	Breast cancer	ICD11: 2C60	[3]

References
1	The changes of bacterial communities and antibiotic resistance genes in microbial fuel cells during long-term oxytetracycline processing. Water Res. 2018 Oct 1;142:105-114.
2	Intestinal bacterial hydrolysis is indispensable to absorption of 18 beta-glycyrrhetic acid after oral administration of glycyrrhizin in rats. J Pharm Pharmacol. 1994 Feb;46(2):135-7.
3	Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63.

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