Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1452) | |||||
|---|---|---|---|---|---|
| DME Name | Unclear metabolic mechanism (DME-unclear), Providencia alcalifaciens | ||||
| Gene Name | DME-unclear | ||||
| Lineage | Species: Providencia alcalifaciens (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 7 Drugs | ||||
Mycophenolate mofetil |
Drug Info | Approved | Crohn disease | ICD11: DD70 | [1] |
Tacrolimus |
Drug Info | Approved | Ulcerative colitis | ICD11: DD71 | [1] |
Danazol |
Drug Info | Approved | Endometriosis | ICD11: GA10 | [1] |
Omeprazole |
Drug Info | Approved | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
Pantoprazole sodium |
Drug Info | Approved | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
Mefloquine hydrochloride |
Drug Info | Approved | Malaria | ICD11: 1F40 | [1] |
Melphalan |
Drug Info | Approved | Multiple myeloma | ICD11: 2A83 | [1] |
| Drugs in Phase 4 Clinical Trial | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
Artemisinin |
Drug Info | Phase 4 | Malaria | ICD11: 1F40 | [1] |
Bisacodyl |
Drug Info | Phase 4 | Irritable bowel syndrome | ICD11: DD91 | [1] |
| Drugs in Phase 2 Clinical Trial | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
Roxatidine |
Drug Info | Phase 2 | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
TU-199 |
Drug Info | Phase 2 | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
| Preclinical/investigative Agents | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Diacetamate |
Drug Info | Investigative | Discovery agent | ICD: N.A. | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | ||||
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