Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1469)
DME Name	Unclear metabolic mechanism (DME-unclear), Variovorax paradoxus
Gene Name	DME-unclear
Lineage	Species: Variovorax paradoxus (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Comamonadaceae Genus: Variovorax Species: Variovorax paradoxus
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human oral cavity.

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs: 1 Drugs
Methotrexate	Drug Info	Approved	Breast cancer	ICD11: 2C60	[1], [2]

References
1	The 46 kDa dimeric protein from Variovorax paradoxus shows faster methotrexate degrading activity in its nanoform compare to the native enzyme. Enzyme Microb Technol. 2016 Apr;85:38-43.
2	Isolation and molecular detection of methylotrophic bacteria occurring in the human mouth. Environ Microbiol. 2005 Aug;7(8):1227-38.

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