Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1489) | |||||
|---|---|---|---|---|---|
| DME Name | VanB ligase (vanB), Desulfitobacterium chlororespirans | ||||
| Synonyms | Vancomycin B-type resistance protein VanB; D-alanylalanine synthetase VanB; D-alanine--D-alanine ligase VanB; D-Ala-D-Ala ligase VanB; vanB | ||||
| Gene Name | vanB | ||||
| UniProt ID | |||||
| EC Number | EC: 6.3.2.4 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Desulfitobacterium chlororespirans (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE
ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKCGEDGAIQGLFVLSGIPYVG CDIQSSAACMDKSLAYILTKNAGIAVPEFQMIDKGDKPEAGALTYPVFVKPARSGSSFGV TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI VLNEVNTLPGFTSYSRYPRMMAAAGITLPALIDSLITLALKR |
||||
| Function | This enzyme produces the depsipeptide D-alanyl-(R)-lactate, which can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Vancomycin |
Drug Info | Approved | Methicillin-resistant staphylococcus infection | ICD11: 1D01 | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense. Microb Biotechnol. 2014 Sep;7(5):456-66. | ||||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.