Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1520)
DME Name Homogentisate 1,2-dioxygenase (hmgA), Variovorax paradoxus
Synonyms Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; HGD; VPARA_16900; hmgA
Gene Name hmgA
UniProt ID
A0A0H2M8H5_VARPD
EC Number    EC: 1.13.11.5     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.5
Lineage    Species: Variovorax paradoxus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Comamonadaceae
Genus: Variovorax
Species: Variovorax paradoxus
Subspecies: Variovorax paradoxus VP-5
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MANPIDNAERRYQSGFGNEYASEAIAGALPQGRNSPQRAPFDLYTELLSGTAFTAPRHEN
RRTWLYRRQPSVVSGRYQPYAQAHWTTGADREIALPPEPLRWHPLPLDGAAEVDFIDGMH
TLAANGDAESQVGIGSLMYLAGRSMERRAFVNADGEMLIVPQQGRLVITTELGVLDVKPG
EIALLPRGMAFKVALPDSDAGAGPSRGYVCENYGAQFRLPELGPIGSNGLANARDFQAPV
AAFEEDGGAYELVKKFGGRFWKAPTKQSPFNVVAWHGNLAPVKYDTANFMVIGSISFDHP
DPSIFTVLTSPSDTPGTANCDFVIFPPRWMVMENTFRPPWFHRNLMSEFMGLVLGEYDAK
PGGFKPGGASLHNCMVPHGPDGEAFDKATHADLKPHKLDNTLAFMFESRYRFIPTNFALR
SPALDTDYADCWAGLNDQFKA
Function This enzyme requires Fe2+ to display activity.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Homovanillic acid
 Drug Info Investigative Brain cancer ICD11: 2A00 [1], [2]
References
1 Isolation and molecular detection of methylotrophic bacteria occurring in the human mouth. Environ Microbiol. 2005 Aug;7(8):1227-38.
2 Degradation of homovanillate by a strain of Variovorax paradoxus via ring hydroxylation. FEMS Microbiol Lett. 1995 Dec 15;134(2-3):213-9.

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