Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1567)
DME Name Cytochrome P450 111A2 (cyp111), Novosphingobium aromaticivorans
Synonyms Cytochrome P450 family 111 subfamily A member 2; Flavocytochrome P450 111A2; P450 111A2; cyp111A2
Gene Name cyp111
UniProt ID
A0A2S6X9I3_9ACTN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Novosphingobium aromaticivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Sphingomonadales
Family: Sphingomonadaceae
Genus: Novosphingobium
Species: Novosphingobium aromaticivorans
Subspecies: Novosphingobium aromaticivorans DSM 12444
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSEETISQTVPPVREWPAIDLPGSDFDPVLTELMREGPVTRISLPNGEGWAWLVTRHDDV
RLVTNDPRFGREAVMDRQVTRLAPHFIPARGAVGFLDPPDHTRLRRSVAAAFTARGVERV
RERSRGMLDELVDAMLRAGPPADLTEALLSPFPIAVICELMGVPATDRHAMHTWTQLILS
SSHGAEVSERAKNEMNAYFSDLIGLRSDSTGEDVTSLLGAAVGRGEITLTEAVGLAVLLQ
IGGEAVTNNSGQMFHLLLSRPELAERLRSDPALRPRAIDELLRWIPHRNAVGLSRIALED
VEVKGARIRAGDAVYVSYLAANRDPEVFPDPDTIDFDRSPNPHVSFGFGPHYCPGGMLAR
LESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW
Function This enzyme is a cytochrome P-450 (heme-thiolate) protein.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Linalool
 Drug Info Investigative Colon cancer ICD11: 2B90 [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005383 Linalool 8-hydroxy-linalool Oxidation - Oxidationn Linalool [2], [3], [4]
References
1 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
2 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
3 Study on the cytochrome P450-mediated oxidative metabolism of the terpene alcohol linalool: indication of biological epoxidation
4 Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes

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