Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1632)
DME Name Aminoglycoside adenylyltransferase (aadA1a), Salmonella enterica
Synonyms Streptomycin 3''-adenylyltransferase; Aminoglycosideadenylyl transferase; aadA; aadA1; aadA1a; ASQ14_26245; ASQ14_27545; FJR52_24735
Gene Name aadA1a
UniProt ID
Q6YLD2_SALER
Gene ID
39727563
EC Number    EC: 2.7.7.46     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.46
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MREAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDE
TTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAG
IFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQDLFEALNETLTLWNSPPDWA
GDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQPVILEARQAYLGQEEDRLA
SRADQLEEFVHYVKGEITKVVGK
Function This enzyme can use ATP, dATP, CTP, ITP and GTP as donors and kanamycin, tobramycin and sisomicin as acceptors. And it mediates bacterial resistance to the antibiotics streptomycin and spectomycin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Spectinomycin
 Drug Info Approved Gonococcal infection ICD11: 1A70 [1]
Streptomycin
 Drug Info Approved Infectious endocarditis ICD11: BB40 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006839 Spectinomycin Unclear Conjugation - O-Adenosine conjugation Spectinomycin [1]
References
1 Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490.

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