Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1637)
DME Name Beta-galactosidase (bgaB), Leptotrichia buccalis
Synonyms Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; 6-phospho-beta-galactosidase; Beta-D-phosphogalactoside galactohydrolase; Lebu_0590; P-beta-Gal; PBG; PGALase; lacG
Gene Name lacG
UniProt ID
LACG_LEPBD
EC Number    EC: 3.2.1.23     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage    Species: Leptotrichia buccalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Leptotrichiaceae
Genus: Leptotrichia
Species: Leptotrichia buccalis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MSKKLPEDFIFGGATAAYQAEGAIKIDGKGPVAWDKFLEENYWYTAEPASDFYHQYPVDL
KLCEEFGINGIRISIAWSRIFPNGYGEVNPKGVEFYHKLFAECKKRKVEPFVTLHHFDTP
EVLHSNGDFLNRENIEHFVNYAKFCFEEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIKY
DFEKLFQSHHNMVLAHAKAVNLFKKNGYHGEIGMVCALPTKYPYDPNNPKDVRAAELDDI
IHNKFILDATFKGEYSKNTMEGVNHILQVNGGKLDLREEDFEELKAAKDLNDFLGINYYM
SDWMAEYDGETEIIHNATGNKGSSKYQIKGVGQRKANESIPRTDWDWIIYPQGLYDQISR
VKKDYPNYKKIYITENGLGYKDVFEDNTVYDDARIDYIRQHLEVISDAIKDGANVKGYFL
WSLMDVFSWSNGYEKRYGLFYVDFETQKRYPKKSAYWYKKVSETKEV
Pathway Galactose metabolism (lba00052 )
Metabolic pathways (lba01100 )
Function This enzyme has 6-phospho-beta-galactosidase activity and galactosidase activity and takes part in lactose catabolic process.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Lactose
 Drug Info Phase 1 Lactose intolerance ICD11: 5C61 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Mannose
 Drug Info Investigative Discovery agent ICD: N.A. [2]
References
1 Lactose metabolism in Streptococcus lactis: studies with a mutant lacking glucokinase and mannose-phosphotransferase activities
2 Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592.

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