Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1674)
DME Name Arylsulfate sulfotransferase (astA), Eubacterium rectale
Synonyms Arylsulfotransferase; Aryl sulfotransferase IV; Arylsulfotransferase; 1-naphthol phenol sulfotransferase; 2-naphtholsulfotransferase; 4-nitrocatechol sulfokinase; Aryl SULT; ArylST; astA
Gene Name astA
UniProt ID
Q9AIW0_9FIRM
EC Number    EC: 2.8.2.22     (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.22
Lineage    Species: Eubacterium rectale     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Eubacterium
Species: Eubacterium rectale
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSVKYSFEDHIVNRQYEAEQEMLKEFEAGNYTIANPLVKYNAYLVNPLSAVVCFHTEKET
AITVTVLGKTPQGNISHTFPKAKKHVLPIVGLYSDYQNRVEIRAYRGESNIITIDVPDVF
DGKEVIYSMDTTPEYLQDNIILVSPAGEDLAVGFDYAGDARWHMTIPCVFDVKRLKNGNL
IMGSHRVIQMPYYMSGLYEISPCGKIYKEFRLPGGYHHDEFEMEDGNLLSLTDDLTSETV
EDMCVLIDRNTGEILKTWDYKKFLDPKKVSKSGSWSDHDWFHNNAVWYDKNTNSLTFSGR
HIDSMVNIDYETGELNWIIGDPEGWPEEMQKYFFKPVGNNFGWQYEQHACVITPDGDVMC
FDNHHYGSKNPEKYLAARDNYSRGVRYKINTDDMTIEQVWQYGKDRGAEFFSPYICNVEY
YNEGHYMVHSGGIAYDTEGNPSEALGAFAKDQGGRLESITVEICDNKKMLDLHVPGNYYR
GEKLKLYSDGINLELGKGQILGEMGVTKEFDTEIPLEPSGEMLPESCNARIEDEIDRFTF
FSRFEKGQLVMLLLEQGEEVHRYFISTTAVPFLAMCCGTFLDSDDRNTRTNINKTGLKGT
YDLRVIIDDKKYETGVTISC
Function This enzyme catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. It's activity is enhanced by Mg2+ and Mn2+.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Laxoberon
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
References
1 The role of intestinal bacteria in the transformation of sodium picosulfate. Jpn J Pharmacol. 1992 May;59(1):1-5.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.