Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1677)
DME Name Beta-glycosidase (glyB), Parabacteroides distasonis
Synonyms Isoflavonoid 7-O-beta-apiosyl-glucoside beta-glycosidase; Peptidoglycan hydrolase; CF162_08980
Gene Name glyB
UniProt ID
A0A3D9A9X6_9BACT
EC Number    EC: 3.2.1.-     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.-
Lineage    Species: Parabacteroides distasonis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides distasonis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRTFSKKKKLPRLLTLCGAVAVSALLGGCGQSGVPAESFDRSDYYTRGIGSYPGDPGEDF
SPSLRPDYSTYRNIALLRSAYNSSSYDYNLTAQLVTDGVISDKQPQYLDLSTQNGDIARR
EREWMIDQGPYSRNAVTGEDAYFLFTLNNWKEKADKVQFRGSVAYDENKIKDGYEIVCEG
SNDGNTWTELAALKGKGMPGKASKYKAHSDPNKNSWDPGTLPTRMLNETLTFDQPGEYAY
YRMRLKMEGAAYWAFFEMNFYNQDKLIDLLPSKFFNSAWMSATTGEEWVYVDLGSQSEFD
KVKLHWINKAIKGKIQVSDDAKQWVDIANLPGGDANLDEIKLKGKGRYVRVWMEQPANDG
RYILSEIEVMGKGGLLAQPAAAPAATKDEIRLSGGNWKVQRASEVTASGEEISKPSFSPE
NWIVATVPGTVLSSYKNIGAIPNPNYADNLMQISESFFNSNFWYRDEFEVPEGFKQDRLF
LNFDGINWKANVYLNGNKIGRIEGAFIRGVFDVTDRVVPGKNVVAVEIIKNEHIGAIKEK
CEKNTDFNGGILGADNPTFHASIGWDWISTIRGRNIGIWDDVYLTSTGKVTIQDPFVQVV
LPLPDTTSATLTPEVIVKNHDAAPVKGVLTGKIGDITFEQPVELAANEEKTVTFDPNSFS
QLKVQNPRLWWPKGYGSPYLYDANFTFKVGDKVSDSEDFKVGIRQMTFNENNSILSLFIN
GRRFIGRGGNWGFGESNLNYRGREYDIAVAYHADMNFTMMRNWVGQIGDKELYEACDRHG
IMIWQDFWLANPSDGPDPYDPEMFIANAEDYVKRFRNHASIGIYCGRNEGFPPEQIDKAL
RRIVKEDHPGLHYISSSADEVVSGHGPYRALPVKEYFSLKNGSDKFHSERGMPNVMNYES
LVRTFSPEALWPQNAQWGQHDYTMEGAQSCASFNAIIEKGFGKPNNAKEFADLAQWVNYD
GYRGMFESRSLNRKGLLLWMTHPAWPSMVWQTYDYYFEPTAAYFGCKKASEPLHIQWNPV
TDEIEVVNYSAGVRNGLTAKAQIINMDGSISWENEVSVDSKEDTTNKCMKLDFPASVSSA
HFVKLTLTENGKIVSDNFYLRGVEEGNYQALREMPKVTLRSNVATNKGNDGTWTATATLE
NTSSTPALMIRVNVIGEKDGQQFLPMFYSDNYFSLLPGEKKEINIHWKDVDTRGEAPKVV
ISGYNVN
Function This enzyme catalyzes the hydrolysis of substrates containing beta-glycoside.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Remogliflozin etabonate
 Drug Info Phase 2 Type-1/2 diabetes ICD11: 5A10-5A11 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
K-6015
 Drug Info Investigative Campylobacter gastroenteritis ICD11: 1A06 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005338 K-6015 Unclear Unclear - Unclear K-6015 [2]
References
1 Assessment of the drug interaction risk for remogliflozin etabonate, a sodium-dependent glucose cotransporter-2 inhibitor: evidence from in vitro, human mass balance, and ketoconazole interaction studies
2 Comparison of anti-Campylobacter activity of free thymol and thymol-beta-D-glucopyranoside in absence or presence of beta-glycoside-hydrolysing gut bacteria. Food Chem. 2015 Apr 15;173:92-8.

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