Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1686)
DME Name D-Lactate dehydrogenase (ldhA), Fusobacterium nucleatum
Synonyms Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; FN0511; ldhA
Gene Name ldhA
UniProt ID
Q8RG11_FUSNN
Gene ID
992792
EC Number    EC: 1.1.1.28     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.28
Lineage    Species: Fusobacterium nucleatum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium nucleatum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MQKTKIIFFDIKDYDKEFFKKYGADYNFEMTFLKVRLTEETANLTKGYDVVCGFANDNIN
KETIDIMAENGIKLLAMRCAGFNNVSLKDVNERFKVVRVPAYSPHAIAEYTVGLILAVNR
KINKAYVRTREGNFSINGLMGIDLYEKTAGIIGTGKIGQILIKILRGFDMKVIAYDLFPN
QKVADELGFEYVSLDELYANSDIISLNCPLTKDTKYMINRRSMLKMKDGVILVNTGRGML
IDSADLVEALKDKKIGAVALDVYEEEENYFFEDKSTQVIEDDILGRLLSFYNVLITSHQA
YFTKEAVGAITVTTLNNIKDFVEGRPLVNEVPQNQ
Structure
3WWY ; 5Z21 ; 6ABI
Pathway Metabolic pathways (fnu01100 )
Microbial metabolism in diverse environments (fnu01120 )
Pyruvate metabolism (fnu00620 )
Function This enzyme has D-lactate dehydrogenase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-053072
 Drug Info Phase 1 Prostate cancer ICD11: 2C82 [1]
References
1 Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. AMB Express. 2014 Oct 28;4:76.

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