Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1726)
DME Name Glycosyl hydrolase (glyH), Marvinbryantia formatexigens
Synonyms Glycosidase; Glycoside hydrolase; Furcatin hydrolase; Isoflavonoid 7-O-apiosylglucosidase; BRYFOR_06869; bglB
Gene Name glyH
UniProt ID
C6LE20_9FIRM
EC Number    EC: 3.2.1.18     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.18
Lineage    Species: Marvinbryantia formatexigens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Marvinbryantia
Species: Marvinbryantia formatexigens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKFTEGYWLRSERANGLFAAEAYAVEKIPGGMRVVAPVTRIGSRGDTLNMPVITIEFRAC
AKGTISVKAWHYEGYDSHLPQFEKKEDIYDADVQISEEEAVLDTGLLKVRVSRKNFGYSF
EADGKVLTSCGFRNLGYMRWDRQVSTMYPADNYLTEAHKPYMVNELSLSVGERVYGFGER
FTAFVKNGQTVDIWNEDGGTASQLAYKNIPFYMTNRGYGVFVDCSDHVSFEVASEKVEYV
GFSVPGESLSYYFFYGPQPKQILNAYTALTGRPALPPAWSFGLWLSTSFTTNYDEETTSF
MIDGMAQRGIPLRVFHFDCFWMKAFHWCDFEWDKDCFPDIRGTLARYHEKGLKICVWINP
YIAQGTPFFKEGAQNGYLLKRADGKGVWQTDNWQAGMGLVDFTNPDAVRWYTGKLKTLLD
CGVDCFKTDFGERIPVNVSYYDGSDPHAMHNYYTFLYNRTVFNLLKEVKGEQEAVLFARS
ATAGCQQFPVHWGGDCFANYPSMAETLRGGLSFAMSGFSFWSHDISGFESTATPDLYKRW
AAFGLLSTHSRLHGSSSYRVPWNFDEEACDVVAFFTKLKCRLMPYLYAKAVEAHREGTPV
MRPMVFEFMEDTAVAYIDTQYMLGEALLVAPIFREDSVCEYYLPEGTWTHLLDGGVKEGG
IWRKETYDYFSLPLYVRENTLLALGADETRPDYAYEEGMSLRLYQLQDGQTAVCRVPDTA
GEIVNVITARRKNAEITLCLEKAAGDIPLTIYDGECTKETVIPAGTGELQVSLED
Function This enzyme does not act on 4-O-acetylated sialic acids and it has no alpha-N-acetylgalactosaminidase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
LS-69767
 Drug Info Phase 1 Chronic myelogenous leukaemia ICD11: 2A20 [1]
References
1 In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.

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