Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1733)
DME Name Beta-lactamase (blaB), Citrobacter koseri
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase TEM; IRT-4; TEM-1
Gene Name blaB
UniProt ID
BLAC_CITKO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Citrobacter koseri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species: Citrobacter koseri
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFKKRGRQTVLIAAVLAFFTASSPLLARTQGEPTQVQQKLAALEKQSGGRLGVALINTAD
RSQILYRGDERFAMCSTSKTMVAAAVLKQSETQHDILQQKMVIKKADLTNWNPVTEKYVD
KEMTLAELSAATLQYSDNTAMNKLLEHLGGTSNVTAFARSIGDTTFRLDRKEPELNTAIP
GDERDTTCPLAMAKSLHKLTLGDALAGAQRAQLVEWLKGNTTGGQSIRAGLPEGWVVGDK
TGAGDYGTTNDIAVIWPEDRAPLILVTYFTQPQQDAKGRKDILAAAAKIVTEGL
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
Cefoxitin
 Drug Info Approved Peritonitis ICD11: DC50 [2]
References
1 Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrob Agents Chemother. 2005 Apr;49(4):1564-6.
2 Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother. 2004 Jun;53(6):1076-80.

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