Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1750)
DME Name	Alpha-hydroxysteroid dehydrogenase (12AH), Clostridium scindens
Synonyms	Hydroxysteroid dehydrogenase alpha; 12-alpha-HSD; 12-alpha-hydroxysteroid dehydrogenase; 12AH; HSD12A
Gene Name	12AH
UniProt ID	12AH_CLOS4
EC Number	EC: 1.1.1.176 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.176
Lineage	Species: Clostridium scindens (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Lachnoclostridium Species: Clostridium scindens
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human gut.
Sequence	MIFDGKVAIITGGGKAKSIGYGIAVAYAK
Function	This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form. Abd it also acts on bile alcohols.

Full List of Drug(s) Metabolized by This DME
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 1 Drugs
Oxolithocholic acid	Drug Info	Investigative	Discovery agent	ICD: N.A.	[1]

References
1	Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18.

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