Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1774)
DME Name Alkaline phosphatase (ALP), Capnocytophaga gingivalis
Synonyms Alkaline p-nitrophenylphosphate phosphatase; Alkaline phenyl phosphatase; Alkaline phosphatase F I; Alkaline phosphatase F II; Alkaline phosphatase HaALP1; Alkaline phosphatase HaALP2; Alkaline phosphatase HvmALP 1; ALKP; ALPase; Alk Phos; Basic phosphatase; 86 kDa homodimeric protein enzyme; CGC50_00990
Gene Name ALP
UniProt ID
A0A250FL93_9FLAO
EC Number    EC: 3.1.3.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.1
Lineage    Species: Capnocytophaga gingivalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Flavobacteriia
Order: Flavobacteriales
Family: Flavobacteriaceae
Genus: Capnocytophaga
Species: Capnocytophaga gingivalis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MERRNFLKNSLLAGLGSLLVPSVAQAQASESFGRKRAKNIIYLVSDGMSIGTLVMADLYS
KRILGRSSAWFSLYEQKLAVKASMDMQSASSVVTDSSAASSSWGSGHRIINGMINVGVNG
EQYTPILQKFKKAGKKVGCVTTVPITHATPAGFCTNSKERKAQPKIAENYLDLRFDVMMG
GGDNYFNAGKRKDKQDMYVKYLEKGFTVVKNVSQMNAAPKNVPLLGVFDKDALPYTLDEN
NTTKNATIPTLAQMTQKAIDMMADHKQGFVLQVEGGKVDWAAHGNDIGALLFDQLAFDDA
VRVAIDFAKKDGNTLVVITSDHGNANPGLIYGKECNKNFDNLAHFLHTNDFTLQSINLTD
SVSQVRDLLTHNFGNIPFSQEEAKEILSFYTEGKQEDGLYNYKKLPYRLLAEIQKKHTSV
GWISMDHSSDYTELAMYGPGSQNLPPFIENYKMHNFLLEAAEVDMLEKY
Pathway Folate biosynthesis (cgh00790 )
Metabolic pathways (cgh01100 )
Thiamine metabolism (cgh00730 )
Two-component system (cgh02020 )
Function This enzyme can catalyse transphosphorylations and has wide specificity.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Fospropofol disodium
 Drug Info Approved Monitored anaesthesia care ICD11: N.A. [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
UDP-galactose
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Triclosan monophosphate
 Drug Info Investigative Discovery agent ICD: N.A. [3]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR014192 Fludarabine phosphate Fludarabine Other reaction - Dephosphorylation Fludarabine phosphate [4]
MR012934 UDP-galactose Galactose Oxidation - Hydrolyzationn UDP-galactose [2]
References
1 DrugBank(Pharmacology-Metabolism):Fospropofol disodium
2 Using a Personal Glucose Meter and Alkaline Phosphatase for Point-of-Care Quantification of Galactose-1-Phosphate Uridyltransferase in Clinical Galactosemia Diagnosis
3 Hydrolysis of triclosan monophosphate by dental plaque and selected species of oral micro-organisms. J Dent Res. 1996 Aug;75(8):1578-84.
4 Prodrugs: design and clinical applications

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