Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1775)
DME Name Glycosyltransferase (Gtf), Actinomyces howellii
Synonyms Archaeal glycosylation protein; Glycosyltransferase/acyltransferase penicillin-binding protein; C3V41_10425; GTF
Gene Name C3V41_10425
UniProt ID
A0A2S0LQ16_9ACTO
EC Number    EC: 2.4.1.155     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.155
Lineage    Species: Actinomyces howellii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Actinomycetaceae
Genus: Actinomyces
Species: Actinomyces howellii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MPEPQEVPALTPSASVIVPSYRGEARLPVLLGGLAQQDTTDFEVVVVIDGEVDASAAVLA
GLGESTGLDLDVIVFPRNRGRVAALNAGHAAARGEVLIRCDDDLLPAPDFVSGHVARHAH
HGPRGVVALANDVMPDSPYARAYGVRSMDHLIASAYAGDIEPWRLWSANCSLTRGTWEQV
GEYSQEYAHYGMEDTDYGYRLHQAGIPLVIAPELQVAHLGAPTSTHDRVMRAFHSGASRR
TFEARHGSALSLPSAGTGPWGRLVDGLSRAGDEPRYERATRAVDRLLPYVPRYVAEKLVA
LCVESASLAGYRHAQDVTASF
Function This enzyme requires Mg2+ and it catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides, and thus enables the synthesis of tri- and tetra-antennary complexes.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Q-44287045
 Drug Info Preclinical Colon cancer ICD11: 2B90 [1]
Macrolactin A
 Drug Info Preclinical Colon cancer ICD11: 2B90 [1]
References
1 A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry. 2009 Oct-Nov;70(15-16):1812-21.

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