Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1778)
DME Name Phospholipase C (plc), Clostridium novyi
Synonyms Phosphatidylcholine cholinephosphohydrolase; Gamma-toxin; PLC; plc
Gene Name plc
UniProt ID
PHLC_CLONO
Gene ID
4541971
EC Number    EC: 3.1.4.3     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric diester hydrolase
EC: 3.1.4.3
Lineage    Species: Clostridium novyi     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium novyi
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKKFLKGLCCAFVISITCLGASSKAYGWDGKKDGTGTHSMIVTQAVKVLENDMSKDEPE
IVKQNFKILQDNMHKFQLGSTYPDYDPNAYKLFQDHFWDPDTDHNFSKDNLWYLSYSIKD
TAESQVRKFTALARNEWEKGNYEKATWYFGQAMHYFGDLNTPYHAANVTAVDSIGHTKYE
GFAEKRKDQYRINTTGIKTNEGFYADALKNSNFDSWSKEYCKGWAKQAKNLYYSHSTMKH
TNEDWDYSASHALKNAQMGTAGCIYRFLYDVSKDLLPTENHKINGLMVVIKTANEIAAGT
DDYVYFGIERKDGTVQEWTLDNPGNDFEANQEDTYILKIKKPSIKFSDINRMWIRKANFT
PVSDDWKVKGIKVIADGSVQYEKQINKWIHGNEKYYIN
Function This enzyme is a bacterial zinc protein, and it acts on sphingomyelin and phosphatidylinositol.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Phosethanolamine
 Drug Info Investigative Parkinsonism ICD11: 8A00 [1]
Spingomyelin
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004589 Phosethanolamine Phosethanolamine Metabolite M1 Hydrolysis - Hydrolyzation Phosethanolamine [1]
MR010094 SRI-62-834 SRI-62-834 Metabolite M2 Unclear - Unclear SRI-62-834 [2]
References
1 Phospholipase C from Clostridium novyi type A. I. Biochim Biophys Acta. 1975 Oct 21;409(1):75-85.
2 Is metabolism an important arbiter of anticancer activity of ether lipids? Metabolism of SRI 62-834 and hexadecylphosphocholine by [31P]-NMR spectroscopy and comparison of their cytotoxicities with those of their metabolites

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