Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1797)
DME Name Sulfide-quinone reductase (SQR), Acidithiobacillus ferrooxidans
Synonyms Sulfide:quinone oxidoreductase; Sulfide dehydrogenase-like; AFE_1792; SQR
Gene Name SQR
UniProt ID
SQRD_ACIF2
EC Number    EC: 1.8.5.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.8.5.4
Lineage    Species: Acidithiobacillus ferrooxidans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Acidithiobacillia
Order: Acidithiobacillales
Family: Acidithiobacillaceae
Genus: Acidithiobacillus
Species: Acidithiobacillus ferrooxidans
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPWVGVGWKERDDIAF
PIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPKLAFENVPGSDPH
EGPVQSICTVDHAERAFAEYQALLREPGPIVIGAMAGASCFGPAYEYAMIVASDLKKRGM
RDKIPSFTFITSEPYIGHLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQ
VDEKGETIKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANIFAA
GIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQTMGTWNAVCFADM
GDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKYFIRKMKMGVSEPFYEKVLFKMMG
ITRLKEEDTHRKAS
Structure
3KPK ; 3SX6 ; 3SXI ; 3SY4 ; 3SYI ; 3SZ0 ; 3SZC ; 3SZF ; 3SZW ; 3T0K ; 3T14 ; 3T2K ; 3T2Y ; 3T2Z ; 3T31
Pathway Sulfur metabolism (afr00920 )
Function This enzyme contains FAD, and in some organisms it catalyses the formation of sulfur globules. And it can catalyze the oxidation of hydrogen sulfide, with the help of a quinone.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Naphthoquinone
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Quinone
 Drug Info Investigative Prostate cancer ICD11: 2C82 [1]
References
1 The quinone-binding site of Acidithiobacillus ferrooxidans sulfide: quinone oxidoreductase controls both sulfide oxidation and quinone reduction. Biochem Cell Biol. 2016 Apr;94(2):159-66.

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