Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1816)
DME Name Glycerol/diol dehydratase (dhaB), Blautia obeum
Synonyms Glycerol dehydratase; Propanediol dehydratase pduC; DWX77_02365; ERS852533_01660; dhaB; pduC
Gene Name dhaB
UniProt ID
A0A174P2C4_9FIRM
EC Number    EC: 4.2.1.30     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.30
Lineage    Species: Blautia obeum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia obeum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKRSKRIEVLDQRPVNKDGFIDEWPEMGFVSMHSPYDPKPSVKIEDGIITELDGKKRDEF
DFLDQFIADYAIRADRAEASMAIPSLEIARKIVDIHVSRKEILEIVSGITPAKMVEVINY
LNVVELMMGMQKMRARKVPGNQAHITNLKDDPVQIAADAAEGALRGFSEEETTMGVARYA
PFSAMALLIGSQTGRPGVLTQCSAEEATELELGIRGLTTYAETLSVYGTEKVFVDGDDTP
YSKAFLNSAYASRGLKVRFTSGAGSEVLMGSSEKKSMLYLECRCLYVTKGCGSQGIQNGS
VSCIGVAAGVPAGIREVMGENLVAALLGLECASSNDQSFSNSDMRRTARTMLQFMPGTDF
IFSGYAAEPNYDNMFAGSNFDAEDFDDYNVLQRDMQVDGGLRPVTEEDVIRVRHEAGKAV
QAVFKYLGLTEVTDEQVEAVTYAHGSKDTLKRDVASDLMAADDMMKRGITGIDVVKALAE
SGYTVLADNILNMLKQRVIGDYMQTAAILDKNFQVMSGVNTPNDYMGPGTGYRVSGKRWE
EIKAIPHRINANDI
Function This enzyme has two forms. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
PhIP
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.

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