Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1846)
DME Name Beta-glucuronidase (uidA), Bacteroides vulgatus
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; DW869_09665; ERS852509_02025; ERS852556_03307; uidA
Gene Name uidA
UniProt ID
A0A174N6T8_BACVU
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Bacteroides vulgatus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides vulgatus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKTLLTICLVWMCFSLSAQKIIDLSGKWSFSIDRQDNGEKEKWFSHTLNDFINLPGSMP
EKLKGDEVTAKTQWTGSLYDSSYYYNPYMEKYRKEGNIKFPFFLTPDKHYVGAAWYQKEV
NIPADWKGERILLFLERPHIETTVWVNGQKTGMQNSLCVPHQYDITRYVRPGKCTITIRV
DNRIKEINVGPDSHSITDQTQGNWNGIVGRICLQTTPKTYFDDIQIYPEPEQKLARVKVV
IKGTGTAKVKLSAESFNTDKKHIVPAIQQEIKLNKGVTETEMVLPMGNDMLLWDEFHPAL
YKLKAEVTNGKKTEIKEIQFGIRRFEIKGKWFYVNGRKTQLRGTVENCDFPLTGYAPMDV
ESWERVFRICRSYGLNHMRFHSFCPPEAAFMAADRVGFYLQPEGPSWPNHGPKLGLGQPI
DKYLMDETIALTKEYGNYASYCMLACGNEPSGRWVEWVTKFVEYWEKKDPRHVYTGASVG
NGWQWQPRNQYHVKAGARGLTWSKKQPSTQDDYRFQNHLDTVRQPYVSHETGQWCAFPNF
NEIRKYTGVNKAKNFEIFKDILADNHMSDQAHLFMMASGKLQALCYKYEIEKTLRTPDYA
GFQLLALNDYSGQGTALVGVLDVFFEEKGYINSAEWRRFCSPTVPLMRTDKFVYNNKEIL
KADIEIAHFGAEALKQAEIVYTLKDEYGKVYAQGTLATQDIPVGNLNRTGSLEFPLTDIQ
EAKKLNLEIRIMGTEAVNDWNFWVYPAQVTIAEGKVYTTDTLDSKALEILQNGGNVLITA
AGKVSYGKEVVQQFTPVFWNTSWFKMRPPHTTGILVNPKHPLFRQFPTEYHSNLQWWELL
NRAQVMQFTHFPPAFQPTVQSIDTWFISRKIGMLFEANVLNGKVLMTSMDITSQPEKRIV
ARQMHKAILDYMNSDQFRPQFTVTPQQISELFTKTAGDIKSYTNDSPDELKPKIN
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Indomethacin glucuronide
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.

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