Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1873)
DME Name Azoreductase (azoR), Fusobacterium nucleatum
Synonyms Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; JW1409; acpD; b1412
Gene Name azoR
UniProt ID
AZOR_ECOLI
Gene ID
947569
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Fusobacterium nucleatum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium nucleatum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSKVLVLKSSILAGYSQSNQLSDYFVEQWREKHSADEITVRDLAANPIPVLDGELVGALR
PSDAPLTPRQQEALALSDELIAELKAHDVIVIAAPMYNFNISTQLKNYFDLVARAGVTFR
YTENGPEGLVTGKKAIVITSRGGIHKDGPTDLVTPYLSTFLGFIGITDVKFVFAEGIAYG
PEMAAKAQSDAKAAIDSIVSA
Structure
1TIK ; 1V4B ; 2D5I ; 2Z98 ; 2Z9B ; 2Z9C ; 2Z9D
Function This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
CTK0H-9987
 Drug Info Phase 2 Trachoma ICD11: 1C23 [1]
References
1 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.