Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1919)
DME Name Sulfatase (sulF), Prevotella buccae
Synonyms Dehydroepiandrosterone sulfatase; Sulfate sulfatase; Cholesterol sulfate sulfohydrolase; Arylsufatase; Arylsulfatase C; AtsA; ASC; HMPREF2983_01415
Gene Name HMPREF2983_01415
UniProt ID
A0A1F0P5Q0_9BACT
EC Number    EC: 3.1.6.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Sulfuric ester hydrolase
EC: 3.1.6.1
Lineage    Species: Prevotella buccae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella buccae
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNMNDKKLIYRNPIYLIGTRFLKLYIIIGLILRIILMHATPGDASFSLGEIVRLLSIGIV
SDFCMAILLALPLLIIYLGLNERKYHRIIGWMIEILLIASFVYVLFFHTIFHEYGGGAPT
IARIFLGWKLFSFSMRFFFPKIRETWRRVSLYLTWAVYVFLFLCVTAGEYIFWGEFGVRY
NFIAVDYLVYTHEVIGNIMESYAIIPMIGMTLLLTVGIIFLQSRHYRFNITKLYGVKMLI
IHLFLYAVLATSAYFILWETHSLKSDNQYVTQLEQNGACDFVIAFQSNKLAYDQFYAMLP
KQECISMYRQLSGLNKDGKKNIGDSLAENRPNIVLITVESLSADFLTRYGNKQNLTPRLD
RLMQESLVFDSLFAAGNRTVRGLEALSLCLPPSAGESIIKRKANRMGNLSVGSVLSRLGY
KSQFIYGGDSYFDNMGDFFSHNGYEVIDRKNIPDNQVTFANIWGVCDEDIFRKSLQVFDT
NNKSGHPFFAQIMTTSNHRPYTYPAGKITVNGDPNTREASVKYTDYAIGKFIDDAKKKVW
FKNTVFIVIADHCASSAGKTSLPIDRYHIPCLVYAPEIIQQEKIEKICSQIDLMPTVLSL
LNLRSSVSFTGQDILAPTYHPRAFMATYQDLGYMEDNRLTVLSPVRNVQQYTLRPLQDGT
YDEQLARKTDEKLVRKAQAYYQYTNLYVKAK
Function This enzyme catalyzes the hydrolysis of sulfate esters.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Micafungin
 Drug Info Approved Candidiasis ICD11: 1F23 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Estrone sulfate
 Drug Info Investigative Discovery agent ICD: N.A. [2], [3]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004740 Micafungin Micafungin Metabolite M1 Unclear - Unclear Micafungin [1]
References
1 #N/A
2 Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946-2956.
3 Regulating gut flora dysbiosis in obese mice by electroacupuncture. Am J Chin Med. 2018 Oct 4:1-17.

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