Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1935)
DME Name Beta-glucuronidase (uidA), Roseburia hominis
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; DWX93_09420
Gene Name uidA
UniProt ID
A0A395VBK3_9FIRM
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Roseburia hominis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia hominis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MLYPRENSVRGVIDLGGVWNFKLGDEKEPGDSFAMGEDTELMAVPASYNDQKDDPKYRNH
YGWAYYERKITVPSYLKGQRLVLRFDAVTHAAKVYLNGRFLTAHKGGFLPFEVDVTDQLV
PGETAELVVAADNRVNHSTLPVGNEGSTAFFGSDNPGVPSVEAAKVWRKPQNLPNFDFFN
YAGINRPVRIYTTPAAYIEDITLVPDIDGDTGVVNYEIKTAGSVCEDEVRIRILDADGNE
VAAADGAGGTVRIPDARLWWPWPGEPYLYTASVTYGEDLYEETFGIRTVAVEGTQFLING
KPFYFKGFGKHEDAAFRGRGLDVCLDVKDINLIHWLNANSFRTSHYPYAEEMYQLCDREG
IVVIDETPAVGIGAGDKIDPYKTFHIREHHEQVLREMIARDKNHPCVVMWSMGNEPDTEH
FPESAYDYWHSLYELTHSIDPADRPVTFVCCQNNYERDLVTRTMDVVCVNRYYGWYNLSG
DLDAACYALNMELDFWEKQNKPVMITEYGADAVAGIHESVPEMFSEEFQKEYYRRQNAEF
DKRSFFIGEQVWNFADFATIQGCMRADGNKKGLFTRDRRPKMAAHYFKERWGQIPNFEYK
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Indomethacin glucuronide
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.

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