Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1958)
DME Name Nitroreductase (NTR), Prevotella copri
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; DW916_02940
Gene Name NTR
UniProt ID
A0A413TUJ8_9BACT
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Prevotella copri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella copri
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MESIKNRTSIRKYAEKEVSEELLNRLLEEAERTPTMGNLQLYSVVVTRSEEGKKALAPAH
FNQPMVTGAPVVLTICADYRRTTLWAENRKGTPGYDNILSFMNAATDALLFTQTFTNLAE
EAGLGTCFLGTTVYMPKMIIDTLKLPKLVMPVATLTIGWPAEHPALSDRLPLRSIIHHEH
FEDYTPEKIDDFYAEKEALEENKEFVRINNVETLAQVFTDIRYTKKDCEAMSQGFLEALK
QQGFI
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrazepam
 Drug Info Phase 3 Insomnia ICD11: 7A00 [1]
References
1 Distinct genetic and functional traits of human intestinal Prevotella copri strains are associated with different habitual diets. Cell Host Microbe. 2019 Mar 13;25(3):444-453.e3.

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