Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2025)
DME Name Carbapenemase (cphA), Citrobacter youngae
Synonyms Versatile beta-lactamase; Versatile hydrolytic beta-lactamase; Beta-lactamase II; Carbapenem-hydrolyzing metallo-beta-lactamase; Metallo-beta-lactamase type 2b; Metallo-beta-lactamase type IIb
Gene Name ampC
UniProt ID
Q8L1M8_9ENTR
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Citrobacter youngae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species: Citrobacter youngae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYY
FTWGKADIANNRPITQNTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTRYWPELTGKQ
WQNISLLHLATYTAGGLPLQIPNEVTNKTALLRFYQNWQPQWAPGAKRLYANSSIGLFGV
LAVKPSGMSYEEAMIRRVLQPLKLTHTWITVPQSEQRDYAWGYRDGKPVHVSPGQLDAEA
YGVKSSIMDMARWVQANMDASHVQEKTLQQGIGLAQSRYWRIGEMYQGLGWEMLNWPVKA
DTIINGSDSKIALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFIPEKNLGIVMLA
NKSYPNPARVDAAWRILEKLQ
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [1]
References
1 Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's R

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