Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2026)
DME Name	Beta-lactamase (blaB), Citrobacter farmeri
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; CI104_26860
Gene Name	blaB
UniProt ID	A0A223JZR3_9ENTR
Gene ID	40043836
EC Number	EC: 3.5.2.6 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Citrobacter farmeri (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Citrobacter Species: Citrobacter farmeri
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNK AKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVV WVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLR KIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSG HKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL
Pathway	beta-Lactam resistance (cfar01501 )
Function	This enzyme hydrolyzes beta-lactam.

Full List of Drug(s) Metabolized by This DME
Drugs in Phase 4 Clinical Trial			Click to Show/Hide the Full List of Drugs: 1 Drugs
Imipenem	Drug Info	Phase 4	Acute pancreatitis	ICD11: DC31	[1]

References
1	Hospital sewage water: a reservoir for variants of New Delhi metallo-beta-lactamase (NDM)- and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Int J Antimicrob Agents. 2018 Jan;51(1):82-88.

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