Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2031)
DME Name Beta-lactamase (blaB), Vibrio vulnificus
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaCARB; DBX26_23310
Gene Name blaCARB
UniProt ID
A0A3B7D7C4_9VIBR
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Vibrio vulnificus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio vulnificus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKLLFLLALMVASPLSHASKLHEDVSLLEQQISGRIGIAVWDTQTDKHWAYRGDERFPL
VGTFKTLACATMLSEMDTGILKKNATATVEKRDMVMWSPIMDKLAGQNVRIEHACEAAML
MNDNTATNLVLSEIGGPKSVMLFLRTIGDKATRLDSAEPSVNEAMPGDKHDTTTPNAMVN
TLETLIDGDALSYESRIQLKIWMQDSKVSDPLMRSVLPSGWSIADRSGAGGNGSLGFNAI
IWKENHKPVYISIYLAETELSLQAREQLIAQISQLILYKYRNI
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [1]
References
1 Carbapenemase VCC-1-producing Vibrio cholerae in coastal waters of Germany. Emerg Infect Dis. 2017 Oct;23(10):1735-1737.

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