Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2045)
DME Name Unclear metabolic mechanism (DME-unclear), Eubacterium ramulus
Gene Name DME-unclear
Lineage    Species: Eubacterium ramulus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Eubacteriaceae
Genus: Eubacterium
Species: Eubacterium ramulus
Subspecies: Eubacterium ramulus DSM 16296
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Daidzein
 Drug Info Phase 4 Dyslipidaemia ICD11: 5C81 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
AS-35335
 Drug Info Phase 2/3 Venous thromboembolism ICD11: BD72 [2]
BRN-0075455
 Drug Info Phase 2/3 Diabetes mellitus ICD11: 5A10 [2]
BIO-300
 Drug Info Phase 2 Prostate cancer ICD11: 2C82 [1]
BRN-0064479
 Drug Info Phase 2 Prostate cancer ICD11: 2C82 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Cyanidin-3-glucoside
 Drug Info Investigative Discovery agent ICD: N.A. [3]
References
1 Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol Lett. 2002 Mar 5;208(2):197-202.
2 Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. J Appl Microbiol. 2000 Dec;89(6):1027-37.
3 Contribution of gut bacteria to the metabolism of cyanidin 3-glucoside in human microbiota-associated rats. Br J Nutr. 2013 Apr 28;109(8):1433-41.

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