Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2057)
DME Name Aminoglycoside 6'-N-acetyltransferase (aacA), Klebsiella pneumoniae
Synonyms Aminoglycoside 6'-N-acetyltransferase type II AAC6'Ib; Aminoglycoside N-acetyltransferase; aac(6')-Ib
Gene Name aac(6')-Ib
UniProt ID
C5MQW3_KLEPO
EC Number    EC: 2.3.1.82     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.82
Lineage    Species: Klebsiella pneumoniae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPI
GYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVT
KIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA
Function This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Gentamicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1]
References
1 Detection of multidrug-resistant Enterobacteriaceae isolated from river waters flowing to the Guanabara Bay and from clinical samples of hospitals in Rio de Janeiro, Brazil. Biomedica. 2019 May 1;39(s1):135-149.

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