Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2063)
DME Name Cytochrome P450 107L2 (cyp107), Streptomyces avermitilis
Synonyms Cytochrome P450 family 107 subfamily L member 2; Cytochrome P450 monooxygenase 107L2; Narbomycin C-12 hydroxylase 107L2; Pikromycin synthase CYP107L2
Gene Name pikC
UniProt ID
PIKC_STRVZ
EC Number    EC: 1.14.15.11     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.11
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDR
ARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLR
PRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVF
PDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHIL
LVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVE
PVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLA
RLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRRGREAGRRTG
Structure
2BVJ ; 2C6H ; 2CA0 ; 2CD8 ; 2VZ7 ; 2VZM ; 2WHW ; 2WI9 ; 3ZK5 ; 3ZPI ; 4B7D ; 4B7S ; 4BF4 ; 4UMZ
Function This enzyme is a P-450 heme-thiolate protein, and it is involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Lauric acid
 Drug Info Investigative Alzheimer disease ICD11: 8A20 [1], [2]
Oligomycin C
 Drug Info Investigative Colon cancer ICD11: 2B90 [3]
References
1 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
2 Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2017 Jan 22;482(4):902-908.
3 Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A

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