Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2072)
DME Name Beta-lactamase (blaB), Roseomonas gilardii
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaP; ROTAS13_00836
Gene Name blaP
UniProt ID
A0A1Q2YQ29_9PROT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Roseomonas gilardii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rhodospirillales
Family: Acetobacteraceae
Genus: Roseomonas
Species: Roseomonas gilardii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MIGRRMGMGAMAALGLGMMAAGPSGARAASGAGKGQAGAGFSALPAVFAGIERRVGGRLG
VAVLDTATGQRAGHREAERFPLTSTFKLLAAAAVLSRVDAGQARLDQRIRYGREKLVAYS
PETEKHAGEEGMTLAAICEAAVTLSDNTAGNLMLEQIGGPAGLTAWLRSIGDTVTRLDRW
ETALNEAEPGDPRDTTSPAAMLASLQRVTLGEALSVGGQAHLTGWLRANKTGDKRLRAGL
PGGWQAGDKTGAGERGTNNDAGLLWPPGESAPILVAAYSTGGTAPSTERDAALAEVAAAI
VAAKGP
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Ceftiofur
 Drug Info Investigative Superficial thrombophlebitis ICD11: BD70 [1], [2]
References
1 Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96.
2 Skin microbiota is the main reservoir of Roseomonas mucosa, an emerging opportunistic pathogen so far assumed to be environmental. Clin Microbiol Infect. 2016 Aug;22(8):737.e1-7.

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