Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2101)
DME Name Glutamate decarboxylase (gadB), Lactobacillus brevis
Synonyms Glutamic acid decarboxylase; Bacterial glutamate--ammonia ligase; gad; gadB
Gene Name gadA
UniProt ID
A0A0B5GI57_LACBR
EC Number    EC: 4.1.1.15     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.15
Lineage    Species: Lactobacillus brevis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus brevis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
AMENYCVSMIAHLWGIPDNEKIYDDFIGTSTVGSSEGCMLGGLALLHSWKHRAKAAGFDI
EDLHSHKPNLVIMSGYQVVWEKFCTYWNVEMRQVPINGDQVSLDMDHVMDYVDENTIGII
GIEGITYTGSVDDIQTLDNLVSEYNKTATMPVRIHVDAAFGGLFAPFVDGFNPWDFRLKN
VVSINVSGHKYGMVYPGLGWIVWRHNTADILPAEMRFQVPYLGKTVDSIAINFSHSGAHI
SAQYYNFIRFGLSGYKTIMQNVRKVSLKLTAALKTYGIFDILVDGSQLPINCWKLADDAP
VGWTLYDLESELAKYG
Function This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
 Drug Info Approved Sickle-cell anaemia ICD11: 3A51 [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR001523 L-glutamate GABA Oxidation - Decarboxylation L-glutamine [3], [4]
References
1 Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and gamma-aminobutyric acid production. Microb Cell Fact. 2018 Nov 19;17(1):180.
2 GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204.
3 Glutamate decarboxylase-dependent acid resistance in orally acquired bacteria: function, distribution and biomedical implications of the gadBC operon. Mol Microbiol. 2012 Nov;86(4):770-86.
4 The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis. Theranostics. 2023 Feb 21;13(4):1355-1369. doi: 10.7150/thno.80544.

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