Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN005)
DME Name Phosphoglycerate kinase 2 (PGK2), Homo sapiens
Gene Name PGK2
UniProt ID
PGK2_HUMAN
EC Number    EC: 2.7.4.6     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.4.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVL
MSHLGRPDGVPMPDKYSLAPVAVELKSLLGKDVLFLKDCVGAEVEKACANPAPGSVILLE
NLRFHVEEEGKGQDPSGKKIKAEPDKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVN
LPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGM
AYTFLKVLNNMEIGASLFDEEGAKIVKDIMAKAQKNGVRITFPVDFVTGDKFDENAQVGK
ATVASGISPGWMGLDCGPESNKNHAQVVAQARLIVWNGPLGVFEWDAFAKGTKALMDEIV
KATSKGCITVIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKILPGVEALSNM
Function Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Lamivudine
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012101 L-FMAUDP L-FMAUTP Unclear - Unclear Clevudine [2]
MR001405 Lamivudine diphosphate Lamivudine triphosphate Other reaction - Phosphorylation lamivudine [3], [4]
References
1 Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94. doi: 10.1128/AAC.01637-05.
2 Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease. Ren Fail. 2014 May;36(4):613-8. doi: 10.3109/0886022X.2014.882240.
3 Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94.
4 Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine Antimicrob Agents Chemother. 2007 Jun;51(6):2130-5. doi: 10.1128/AAC.01543-06.

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