Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN058)
DME Name Deazaflavin-dependent nitroreductase (SAML1065), Streptomyces ambofaciens
Gene Name SAML1065
UniProt ID
A3KK16_STRA7
EC Number    EC: 5.1.3.1     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Carbohydrate racemase/epimerase
EC: 5.1.3.1
Lineage    Species: Streptomyces ambofaciens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinomycetota
Class: Actinomycetes
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces ambofaciens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MLTKEIAAHARERRSRRHGDHGASPTWGSPMSSATYYRKGSKANVRLNSVIGWLARHGLS
LAGAAEMSVRGRKSGQMQRIPVNPHTHGDGQYLVSARGHSQWVRNMRVAGGGELRVGRRI
RSFTAVELPDEEKLPILRTYLEKWGWEVNQYFQGVTATSSDEEIVAAAEDHPVFRIEVRD
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Pretomanid
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR002133 Pretomanid Des-nitroso derivative, Pretomanid Reduction - Reduction Pretomanid [1]
References
1 Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid ACS Med Chem Lett. 2017 Nov 13;8(12):1275-1280. doi: 10.1021/acsmedchemlett.7b00356.

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