Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN110)
DME Name Cysteine dioxygenase type 1 (CDO1), Homo sapiens
Gene Name CDO1
UniProt ID
CDO1_HUMAN
EC Number    EC: 1.13.11.20     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.20
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTR
NLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKK
SERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMT
FHSKFGIRTPNATSGSLENN
Structure
2IC1 ; 6BGF ; 6BGM ; 6BPR ; 6BPS ; 6BPT ; 6BPU ; 6BPV ; 6BPW ; 6BPX ; 6CDH ; 6CDN ; 6E87 ; 6N42 ; 6N43
Function Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
E-920
 Drug Info Phase 1 Lung cancer ICD11: 2C25 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003891 E-920 3-sulfino-alanine Unclear - Unclear E-920 [1]
References
1 The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase

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