Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN170)
DME Name Lactoylglutathione lyase (GLO1), Homo sapiens
Gene Name GLO1
UniProt ID
LGUL_HUMAN
EC Number    EC: 4.4.1.5     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-sulfur lyase
Carbon-sulfur lyase
EC: 4.4.1.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
Structure
1BH5 ; 1FRO ; 1QIN ; 1QIP ; 3VW9 ; 3W0T ; 3W0U ; 7WSZ ; 7WT0 ; 7WT1 ; 7WT2
Function Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione . Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B . Required for normal osteoclastogenesis (By similarity).
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Methylglyoxal
 Drug Info Investigative Alzheimer disease ICD11: 8A20 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004254 HTA SLG Unclear - Unclear Methylglyoxal [1]
References
1 Cells producing their own nemesis: understanding methylglyoxal metabolism

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