Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN190)
DME Name Hydrogenase-1 small chain (hyaA), Escherichia coli
Gene Name hyaA
UniProt ID
MBHS_ECOLI
Gene ID
945579
EC Number    EC: 1.12.99.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Acting on hydrogen as donor
With unknown physiological acceptors
EC: 1.12.99.6
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Escherichia coli
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNNEETFYQAMRRQGVTRRSFLKYCSLAATSLGLGAGMAPKIAWALENKPRIPVVWIHGL
ECTCCTESFIRSAHPLAKDVILSLISLDYDDTLMAAAGTQAEEVFEDIITQYNGKYILAV
EGNPPLGEQGMFCISSGRPFIEKLKRAAAGASAIIAWGTCASWGCVQAARPNPTQATPID
KVITDKPIIKVPGCPPIPDVMSAIITYMVTFDRLPDVDRMGRPLMFYGQRIHDKCYRRAH
FDAGEFVQSWDDDAARKGYCLYKMGCKGPTTYNACSSTRWNDGVSFPIQSGHGCLGCAEN
GFWDRGSFYSRVVDIPQMGTHSTADTVGLTALGVVAAAVGVHAVASAVDQRRRHNQQPTE
TEHQPGNEDKQA
Structure
3UQY ; 3USC ; 3USE ; 4GD3 ; 4UE3 ; 5A4F ; 5A4I ; 5A4M ; 5ADU ; 5JRD ; 6FPI ; 6FPW ; 6G7R ; 6GAL ; 6RP2
Function This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitroimidazole
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012895 Nitroimidazole Nitroimidazole Metabolite M6 Reduction - Reduction Nitroimidazole [2]
References
1 Reduction of 2-, 4- and 5-nitroimidazole drugs by hydrogenase 1 in Clostridium pasteurianum
2 U. S. FDA Label -Nitroimidazole

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