Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN196)
DME Name Cytochrome b5 type B (CYB5B), Homo sapiens
Gene Name CYB5B
UniProt ID
CYB5B_HUMAN
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHP
GGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCK
SCWAYWILPIIGAVLLGFLYRYYTSESKSS
Structure
3NER
Function Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
NSC-63853
 Drug Info Investigative Discovery agent ICD: N.A. [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012911 NSC-63853 17-alpha-hydroxyprogesterone Unclear - Unclear NSC-63853 [3]
References
1 Blood levels and production rate of 17-hydroxypregnenolone in man
2 The role of cytochrome b5 in the biosynthesis of androgens by human P450c17
3 CONVERSION OF 17-ALPHA-HYDROXYPREGNENOLONE TO 17-ALPHA-HYDROXYPROGESTERONE BY THE CANINE TESTIS IN VIVO

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