Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN381)
DME Name Ornithine aminotransferase (OAT), Homo sapiens
Gene Name OAT
UniProt ID
OAT_HUMAN
EC Number    EC: 2.6.1.13     (Click to Show/Hide the Complete EC Tree)
Transferase
Transaminase
Transaminase
EC: 2.6.1.13
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV
ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL
GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR
TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV
PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP
VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL
MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI
KEDELRESIEIINKTILSF
Structure
1GBN ; 1OAT ; 2BYJ ; 2BYL ; 2CAN ; 2OAT ; 5VWO ; 6HX7 ; 6OIA ; 6V8C ; 6V8D ; 7JX9 ; 7LK0 ; 7LK1 ; 7LNM ; 7LOM ; 7LON ; 7T9Z ; 7TA0 ; 7TA1 ; 7TED ; 7TEV ; 7TFP ; 8EZ1
Function Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-Proline
 Drug Info Approved Malnutrition ICD11: 5B50-5B71 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Proline
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008814 P5C Ornithine Unclear - Unclear L-Proline [1]
MR007607 Delta-1-pyrroline-5-carboxylic acid Ornithine Unclear - Unclear Proline [2]
References
1 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses
2 Proline metabolism in cancer

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.