Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN397)
DME Name Cytochrome P450 105A3 (cyp105A3), Streptomyces carbophilus
Gene Name cyp105A3
UniProt ID
CPS2_STRCC
EC Number    EC: 1.14.-.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Oxygen paired donor oxidoreductase
EC: 1.14.-.-
Lineage    Species: Streptomyces carbophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Streptomyces carbophilus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MTEMTEKATTFLTSQEAPAFPADRTCPYQLPTAYSRLRDEPDALRPVTLYDGRRAWVVTK
HEAARRLLADPRLSSDRLHADFPATSPRFKAFRQGSPAFIGMDPPEHGTRRRMTISEFTV
KRIKGMRPDVERIVHGFIDDMLAAGPTADLVSQFALPVPSMVICHMLGVPYADHEFFQDA
SKRLVQAVDADSAVAARDDFERYLDGLITKLESEPGTGLLGKLVTHQLADGEIDRAELIS
TALLLLVAGHETTASMTSLSVITLLEHPDQHAALRADPSLVPGAVEELLRVLAIADIAGG
RIATADIEIDGQLIRAGEGVIVTNSIANRDSSVFENPDRLDVHRSARHHLSFGYGVHQCL
GQNLARLELEVILTVLFDRIPTLRLAVPVEQLTLRPGTTIQGVNELPVTW
Function Catalyzes the hydroxylation of sodium ML-236B carboxylate to pravastatin.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
ML-236B
 Drug Info Preclinical Hypertriglyceridaemia ICD11: 5C80 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006984 ML-236B pravastatin Oxidation - 6-hydroxylation ML-236B [1]
References
1 Hydroxylation of Steroids by a Microbial Substrate-Promiscuous P450 Cytochrome (CYP105D7): Key Arginine Residues for Rational Design

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