Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN732)
DME Name Guanidinoacetate N-methyltransferase (GAMT), Homo sapiens
Gene Name GAMT
UniProt ID
GAMT_HUMAN
EC Number    EC: 2.1.1.2     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSK
GGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDV
APTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKS
KYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG
Structure
3ORH
Function Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor . Important in nervous system development .
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012749 Guanidinoacetate Creatine Unclear - Unclear Arginine [1]
References
1 Arginine Metabolism Revisited

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