Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN735)
DME Name Protoporphyrinogen oxidase (PPOX), Homo sapiens
Gene Name PPOX
UniProt ID
PPOX_HUMAN
EC Number    EC: 1.3.3.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
With oxygen as acceptor
EC: 1.3.3.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG
IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP
PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI
RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL
ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA
PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP
PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP
QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS
Structure
3NKS ; 4IVM ; 4IVO
Function Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012757 Protoporphyrinogen IX Protoporphyrin IX Unclear - Unclear Aminolevulinic Acid Hydrochloride [1]
MR012732 Hydroxyurea Acetohydroxamic acid Other reaction - Breakdown Hydroxyurea [2]
References
1 Molecular and Metabolic Mechanisms Underlying Selective 5-Aminolevulinic Acid-Induced Fluorescence in Gliomas
2 American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1065

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