Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN736)
DME Name Ferrochelatase (FECH), Homo sapiens
Gene Name FECH
UniProt ID
HEMH_HUMAN
EC Number    EC: 4.98.1.1     (Click to Show/Hide the Complete EC Tree)
Lyases
ATP-independent chelatases
Forming coordination complexes
EC: 4.98.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Structure
1HRK ; 2HRC ; 2HRE ; 2PNJ ; 2PO5 ; 2PO7 ; 2QD1 ; 2QD2 ; 2QD3 ; 2QD4 ; 2QD5 ; 3AQI ; 3HCN ; 3HCO ; 3HCP ; 3HCR ; 3W1W ; 4F4D ; 4KLA ; 4KLC ; 4KLR ; 4KMM ; 4MK4 ; 7CT7 ; 7CTC
Function Catalyzes the ferrous insertion into protoporphyrin IX.
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012758 Protoporphyrin IX Heme Unclear - Unclear Aminolevulinic Acid Hydrochloride [1]
MR012733 Arginine L-Agmatine Unclear - Unclear Arginine [2]
References
1 Molecular and Metabolic Mechanisms Underlying Selective 5-Aminolevulinic Acid-Induced Fluorescence in Gliomas
2 Arginine Metabolism Revisited

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