Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN780)
DME Name L-proline trans-4-hydroxylase (P4H), .
Gene Name P4H
UniProt ID
PROHY_STRGD
EC Number    EC: 1.14.11.57     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
2-oxoglutarate donor oxidoreductase
EC: 1.14.11.57
Lineage    Species: .     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: .
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSVSAPLLDAKVRYGRDGWLPLPHTLSDPDVRKLRQRIEGISREQRPEVVLEEGSSAVRA
LHGCHDFDEVCARLVRLPALVGLAEQLLGGPVYVYQFKVNMKQAHEGAAWPWHQDFAFWH
HEDGMGAPDAVNIAIFLDDVTDENGPLEVIPGSQHAGIVEDTARPGRERSHDWRHHVSAK
LEYVVPDEIAGRLAGTFGVRRLTGPAGTAVAFHPSIIHSSSNNTSAQRRCVLLITYNRVT
NTPAHPVRPPFLVSRDSTPVVPVDADRL
Function Involved in the biosynthesis of the peptidolactone antibiotic etamycin (viridogrisein) . Catalyzes the hydroxylation of free L-proline at the C-4 position to yield trans-4-hydroxy-L-proline .
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-Proline
 Drug Info Approved Malnutrition ICD11: 5B50-5B71 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008803 L-Proline Hydroxy-L-proline Unclear - Unclear L-Proline [1]
References
1 Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation

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