Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DMEN842) | |||||
|---|---|---|---|---|---|
| DME Name | Skin sulfhydryl oxidase (Qsox1), Mus musculus | ||||
| Gene Name | Qsox1 | ||||
| UniProt ID | |||||
| EC Number | EC: 1.8.3.2 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Mus musculus (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Detected in skin (at protein level) . Expressed in the seminal vesicles and skin. . | ||||
| Sequence |
MRRCGRLSGPPSLLLLLLLLSPLLFSGPGAYAARLSVLYSSSDPLTLLDADSVRPTVLGS
SSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCAEETNSAVCREFNIAG FPTVRFFQAFTKNGSGATLPGAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLNDID GFFTRNKADYLALVFEREDSYLGREVTLDLSQYHAVAVRRVLNTESDLVNKFGVTDFPSC YLLLRNGSVSRVPVLVESRSFYTSYLRGLPGLTRDAPPTTATPVTADKIAPTVWKFADRS KIYMADLESALHYILRVEVGKFSVLEGQRLVALKKFVAVLAKYFPGQPLVQNFLHSINDW LQKQQKKRIPYSFFKAALDSRKEDAVLTEKVNWVGCQGSEPHFRGFPCSLWVLFHFLTVQ ANRYSEAHPQEPADGQEVLQAMRSYVQFFFGCRDCADHFEQMAAASMHQVRSPSNAILWL WTSHNRVNARLSGALSEDPHFPKVQWPPRELCSACHNELNGQVPLWDLGATLNFLKAHFS PANIVIDSSASRHTGRRGSPEATPELVMDTLKLESRNSVLGHEQAASAESPGATALDVPA EKPEASGPQELYTGLRMGGASPGQGPPERMEDHQRDMQENAPGQQHLSKRDTEALFLPEV NHLQGPLELRRGGRSPKQLAPILEEEPEALAIQGQGQWLQVLGGGISHLDISLCVGLYSV SFMGLLAMYTYFRARLRTPKGHASYPTA |
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| Structure | |||||
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide . Plays a role in disulfide bond formation in a variety of extracellular proteins . In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration . | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Penicillamine |
Drug Info | Approved | Rheumatoid arthritis | ICD11: FA20 | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Skin sulfhydryl oxidase. Purification and some properties | ||||
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