Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DMEN853) | |||||
|---|---|---|---|---|---|
| DME Name | Acetylcholinesterase (ACHE), Oryctolagus cuniculus | ||||
| Gene Name | ACHE | ||||
| UniProt ID | |||||
| EC Number | EC: 3.1.1.7 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Oryctolagus cuniculus (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Sequence |
AEGREDPELLVTVRGGRLRGLRLKAPGGPVSAFLGIPFEEPPVGPRRFLPPEPKRPWAGV
LDATAFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIY GGGFYSGASSLDVYYGRFLVQAEGTVLVAMNYRVGAFGFTCLPGSREAPGNVGLLDQRLA LQWVQENVAAFGGDPASVTLFGESAGAASVGLHLLSPPSRGLFHRAVLQSGAPNGPWATV GVGEARRRATLLARLVVCPPGGAGGNDTELVACLRTRPAQDLVDHEWRVLPQESIFRFSF VPVVDGDFLSDTPEALINAGDFQGLQVLVGVVKDEGTYFLVYGAPGFSKDNESFISRAQF LAGVRVGVPQASDLAAEAVVLHYTDWLHPEDPARLRDALSDVVGDHNVVCPVAQLAGRLA AQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGLPLEPSLNYTEEERIFAQRLMRY WANFARTGDPNEPRDAKAPQWPPYTAGAQQYVSLNLRPLEVRRGLRAQACAFWNRFLPKL LSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL |
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| Function | Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Dipivefrin |
Drug Info | Approved | Glaucoma | ICD11: 9C61 | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride | ||||
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